Effect of Spasticity

The purpose of this study is to compare motor neuron properties in adolescents and adults with and without spastic cerebral palsy (sCP).

 

Effect of Spasticity on Motor Neuron Properties

Spasticity effect on motor neuron properties

 

Inclusion Criteria:

  • Individuals with sCP:
    • Age 15 or older with a known diagnosis of cerebral palsy and spasticity.
  • Individuals without sCP:
    • Age 15 and older

Exclusion Criteria: 

  • Individuals with sCP:
    • Botulinum toxin injection to the muscle of interest in the past 3 months
    • A history of phenol neurolysis to the fibular nerve or sciatic nerve
    • Active titration of oral baclofen or anti-epileptic medications
    • History of a selective dorsal rhizotomy
    • Presence of a baclofen pump
    • Having any other neuromuscular disorder
  • Individuals without sCP:
    • Presence or history of a peripheral or compressive neuropathy
    •  Myopathy
    • Injury to the nerve or muscle of interest
    • Abnormality of the central nervous system (stroke, traumatic brain injury (with presence of spasticity or movement difficulties), spinal cord injury, neurodegenerative condition, or central nervous system tumor)
    • Any other neuromuscular disorder

If you need assistance understanding the eligibility criteria, please contact the study team.

 

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